Ortho Max proudly distributes STIMULAN® for the State of Florida. Contact your local STIMULAN® sales representative . . .
STIMULAN®
STIMULAN—a pharmaceutical-grade calcium sulfate that is the perfect partner for cases with an infected site—may help improve surgical outcomes, and lower overall costs of care.
Perfect partner for cases with an infected site
STIMULAN is a truly absorbable calcium sulfate, specifically designed to complement your dead space management.1
- Cleared for placement directly at site of infection in bone voids and defects
Calcium sulfate uniquely recrystallized for consistent and reliable performance in the presence of infection
STIMULAN Bullet Mat and Introducer
- Simplify delivery into hard-to-reach defects.
- Mold long bullets with a groove down one side to reduce the risk of pressurizing the defect site.
- Bullet can be prepared in two diameters – 7mm and 9mm for varying void sizes.
| Bullet diameter | Outside diameter of introducer | Minimum reamed diameter | End-to-end length | Order Code |
|---|---|---|---|---|
| 7mm | 9mm (black handle) | 10mm | 640mm | 660-001 |
| 9mm | 11mm (silver handle) | 12mm | 480mm |
Reference: 1. Biocomposites Ltd, STIMULAN Instructions for Use.
For indications, contraindications, warnings and precautions see Instructions for Use. Concurrent use of locally administered antibiotics may affect setting time.
This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.
©2017, Biocomposites, STIMULAN, Bringing Calcium to Life and Power to Transform are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.
Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710
Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9
Recrystallized for consistent and reliable performance
STIMULAN has a unique crystal structure and properties.
- controlled purity
- physiologic pH level
- hydrophilicity
Only STIMULAN undergoes a patented recrystallization process that starts with pharmaceutical-grade reagents and results in its consistent and reliable performance.1
- truly absorbable
- absorbs at an optimal rate
- no third body damage
Hydrophilic for fast, easy mixing
No soaking required.
STIMULAN-mixes with liquid
Competitor calcium sulfate–repels liquid
Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate1
Leaves no nidus for infection.
No third body damage2
Less scratching than competitor calcium sulfate and PMMA.
STIMULAN does not damage total knee replacements when trapped between the articulating surfaces of the implant.
For indications, contraindications, warnings and precautions see Instructions for Use. Concurrent use of locally administered antibiotics may affect setting time.
This page may include the use of STIMULAN or techniques that go beyond the current clearance/ approval granted by the relevant regulatory authority. Please contact your local representative for further information.
©2017, Biocomposites and STIMULAN are registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.
Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710
Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328.
Case-by-case flexibility
STIMULAN can be used in three bead sizes, two bullet sizes, as a paste or for injection, for optimized packing in bone voids and defects. Its hydrophilic properties and options of rapid or standard setting times make it quick and easy to prepare – helping you to adapt to each case as is merited.
Flexible formats to optimize dead space management
| STIMULAN | Paste Volume | Bead Volume | Setting Time | Order Codes |
|---|---|---|---|---|
| Kit (standard setting) Fully injectable paste with individual bead kit |
5 cc | 10 | Approx. 8 minutes |
600—005 |
| 10 cc | 20 cc | 600—010 | ||
| Rapid Cure Rapid setting paste with individual bead kit |
5 cc | 12 cc | Approx. 4 minutes |
620—005 |
| 10 cc | 25 cc | 620—010 | ||
| 20 cc | 50 cc | 620—020 |
STIMULAN Bullet Mat and Introducer
- Simplify delivery into hard-to-reach defects.
- Mold long bullets with a groove down one side to reduce the risk of pressurizing the defect site.
- Bullet can be prepared in two diameters – 7mm and 9mm for varying void sizes.
| Bullet diameter | Outside diameter of introducer | Minimum reamed diameter | End-to-end length | Order Code |
|---|---|---|---|---|
| 7mm | 9mm (black handle) | 10mm | 640mm | 660-001 |
| 9mm | 11mm (silver handle) | 12mm | 480mm |
©2018, Biocomposites, STIMULAN, Bringing Calcium to Life and Power to Transform are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.
Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710
Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9
Outcomes
STIMULAN can be used in cases with an infected site to fill a bone void or defect created by a cyst, tumour, traumatic injury or osteomyelitis.
Infected subtrochanteric fracture
Patient presented with: infected femoral nail and non-union of left femur with persistent discharging wounds proximally and distally.
Outcome: at 7 months follow-up there was complete healing of the non-union and at 1 year patient remains infection free, walking with no pain.
Osteomyelitis caused by Group B streptococcus and MRSA
Patient presented with: drainage issues, 1 year after pilon fracture repair and then 2 weeks after hardware removal.
Outcome: 6 months after treatment the patient was fully weight-bearing and without restrictions on activity – with complete absorption of STIMULAN.
Bilateral high energy femoral fractures
Patient presented with: right open comminuted distal femoral fracture and tibial plateau fracture, and left closed comminuted femoral shaft fracture.
Outcome: complete absorption of STIMULAN and healing of the femoral defect after 4 months.
At 1 year, patient was fully independently ambulatory with no pain.
©2017, Biocomposites, STIMULAN, Bringing Calcium to Life and Power to Transform are trademarks/registered trademarks of Biocomposites Ltd. All rights reserved. No unauthorised copying, reproduction, distributing or republication is allowed unless prior written permission is granted by the owner, Biocomposites Ltd.
Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, CN ZL201210466117.X, GB2496710
Patents pending: GB1502655.2, EP 16154210.5, US 15/040075, CN 201610089710.5, US 15/288328, GB1704688.9
Technique Guide Videos
How to prepare STIMULAN Rapid Cure
See the STIMULAN Bullet Mat and Introducer in action
Testimonials
Hear what surgeons have to say about STIMULAN
Case Studies – Surgeon Videos
Dr Wassef
Infected hip revision with STIMULAN beads
Dr Webb
Bilateral high energy femoral fractures with STIMULAN beads
Dr Hohman
Tibial osteomyelitis with STIMULAN beads.
Frequently Asked Questions
Q. What is STIMULAN indicated for?
Q. What is STIMULAN contraindicated for?
Q. Who is using STIMULAN and in which hospitals?
STIMULAN is already used in over 20,000 cases a year. We are happy to introduce physicians to an appropriate surgeon if they would like to have a peer to peer conversation.
Q. Does STIMULAN damage articulating surfaces on joint prosthesis?
This is an area of ongoing research but biomechanical testing (pin on plate) indicates that STIMULAN does not significantly scratch implant grade cobalt chrome and does not lead to increased wear of high density polyethylene components, when compared to a control with no STIMULAN present.
Q. Will STIMULAN cause heterotopic ossification (HO) in soft tissue?
STIMULAN is an osteoconductive material and is not osteoinductive or osteogenic in nature. Biocomposites has published a range of clinical data indicating a minimal risk of HO if implanted in soft tissue.
Q. Why is there so little drainage associated with STIMULAN?
STIMULAN is a pharmaceutical-grade, synthetic calcium sulfate. The physical and chemical properties are tightly controlled through Biocomposites’ patented recrystallisation process to ensure optimum purity. Evidence has shown that STIMULAN is associated with reduced drainage rates when compared to non-synthetic calcium sulfates. Naturally occurring mineral sources of calcium sulfate can contain non absorbing earth impurities, may be of acidic pH and hydrophobic in nature, and are often linked to significant problems with wound healing and drainage.
Q. Can wound drainage occur with the use of STIMULAN?
Wound drainage may occur with any implanted material. STIMULAN has a low documented occurrence of wound drainage. It may be attributed to several factors including patient health and surgical methods e.g. 1) large volumes of STIMULAN beads placed in a concentrated area may cause stretching of the tissue envelope during normal range of motion and leakage at the wound site, 2) patients with comorbidities have a much greater probability of draining due to their poor tissue quality, which may not permit a watertight seal. To reduce the risk of drainage ensure complete soft tissue coverage and/or containment is achieved.